Direct antiglobulin test (Coomb’s-DAT) principle, procedure

Direct antiglobulin test or direct Coomb’s test is an important test for the diagnosis of haemolytic disease in newborns. Sometimes IgG sensitizes the RBC but it cannot produce agglutination. Due to the small size of IgG, it is unable to overcome the force that causes rbc to repel one another, resulting in a failing cross-linked … Read more