A liver function test (LFT test) is an important test for measuring a particular biomarker in the blood. It helps in the (1) diagnosis of liver disease,(2) monitoring therapy, (3) assessing the prognosis.
|Serum total Bilirubin||3-17 micromol/litter|
|Alanine aminotransferase (ALT)||up to 42 u/l|
|Asparatate amino transferase(AST)||up to 37 u/l|
|Serum Alkaline Phosphatase (ALP)||60-306 u/l|
|Total Protein||60-80 g/l|
|Gamma Glutamyltransferase GGT||11- 60 u/l|
There are two groups of tests used to assess liver disease.
- Routine LFT
- Special LFT
What are the Routine Liver Function Test (LFT) name
Routine LFTs include six serum (S) tests.
- Serum alanine aminotransferase (ALT or SGPT )
- Serum Alkaline phosphatase (ALP)
- Serum Bilirubin
- Total protein and Albumin
- S. Gamma-glutamyl transferase (GGT)
- S. 5-Nucleotidase
- Serum Ammonia
NOTE: Serum albumin range shows the synthetic function of the liver. while bilirubin indicated the excretory function of the liver. ALT and AST directly link to liver damage. The rest of the test, GGT, ALP, and 5- nucleotidase relates to liver obstruction.
What are the Special LFT Test name
Following are the six special LFT tests.
- Serum iron and copper
- Hepatitis Markers
- Prothrombin time
- Blood ammonia
- Liver biopsy
when to worry about alt levels?
Liver function tests rise when the hepatocyte is damaged by the pathogen. When is mid-damage, there will be a mild change in ALT, AST, and bilirubin. But when their severe damage, the owing changes in results will occur.
- ALT will be more than 42 U/litter.
- AST will be higher than 37 U/litter.
- Serum Albumin is less than 65 g/l.
Can a liver function test detect cancer?
A liver function test can detect damaged liver cells. When there is a malignancy or infiltration, the following LFT test value alter.
- Aminotransferase (ALA) will increase
- Alkaline Phosphatase (ALP) will raise.
- Albumin can be decreased or normal
- Prothrombin, Bilirubin, GGT all these tests will be normal.
Why is liver function elevated?
Liver function tests range (serum bilirubin, ALT, AST, GGT, ALP) directly link hepatocyte function. When liver cells are damaged due to the virus (HBV, HCV ) results in the elevation of liver function test.
will the liver function test show liver damage?
The answer to this question is YES. ALT and AST enzyme range in the serum is directly linked to hepatocytes. When liver cells are attacked by any kind of pathogen like HBV or HCV, alanine aminotransferase and aspartate aminotransferase rises.
Can a liver function test detect cirrhosis?
Yes, a liver function test (LFT test) can detect cirrhosis. Cirrhosis is the end stage of liver disease. At this stage, the liver stops its synthesis and neutralizing functions.
At this stage, albumin decreases, ALT, AST, bilirubin, ALP, GGT range will increase.
Can liver function tests be normal with liver disease?
Liver function tests can be normal with liver disease, but IF the disease is at its initial stage and it did not damage more liver cells, But in the late stage, ALT (SGPT), and AST, will raise in the blood.
Liver function test ALT
ALT is the short-term for alanine aminotransferase. ALT is a special test for detecting hepatic cell damage. ALT and AST levels tend to increase during the onset of viral attacks.
Liver function test ALT normal range
Aspartate aminotransferase (AST) normal is between 0 to 37 micro/litter.
Does a liver function test require fasting?
In most cases, no fasting is required for liver function tests (LFT test). But some laboratories asked for fasting before collecting LFT test samples.