differences between type 1 and type 2 diabetes

7 KEY differences between type 1 and type 2 diabetes

Diabetes is associate with a rise in blood sugar levels. The main difference between type 1 and type 2 diabetes is that type.

  • Type 1 occurs at an early age. while type 2 occurs at a late age.
  • Type 1 occurs due to autoimmune destruction of beta-cell of the pancreas.
  • In this case, there is an absolute deficiency of insulin in the blood.
  • Type 2 diabetes at late age or middle of age.¬†¬†
  • Most obese patients have type 2.
  • This type of diabetes occurs due to impaired insulin secretion or resistance to insulin.¬†
  • Obesity and under-activity are the main causes of type 2 diabetes.¬†

In this disease blood, sugar level is directly linked to Insulin in the blood. Deficiency of Insulin results in raise in blood sugar levels.  Here we are going to compare both types of Diabetes

 Type 1 vs 2 diabetes

Type 1 Diabetes

Features
Clinical Symptoms:     1) Normal weight
                                       2)Progressive decline in insulin levels
                                       3)Autoantibodies
                                        4)Childhood and
                                         adolescence
Pathology:                     Insulitis
Pathogenesis:             Major linked to MHC
                                      Class 1 and 2 genes
Genetic:  Dysfunction in regulatory T cell leading to a breakdown in self-tolerance to Islet autoantigen.

Type 2 Diabetes symptoms

Features:    Most patients are obeseClinical Symptoms: Blood insulin Levels are normal

Pathology:    No Insulitis, Amyloid   Deposition in pancreatic cells.

Pathogenesis:  No HLA linkage     

Genetic:        Insulin Resistance  

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